Yes, there are very different rules. In a nut shell:
1. You play with 99 cards in your deck. With the exception of Basic Lands, you may not have more than 1 copy of any card. This is called a "Singleton" format.
2. You must choose a Legendary Creature (not a Planeswalker) to act as you Commander/General. The Commander's colors determine your deck's "color identity", and what cards you can play.
3. You may not have cards outside your color identity. For example, if you
Nicol Bolas as your commander, you may only build your deck with Blue, Black, and Red cards. They also cannot have abilities that require anything outside that color.
4. Your Commander is not part of your deck, he stays in a special "Command Zone", where you can cast him from at any time you normally could cast him from your hand. So if you had
Teferi, you could cast him at Instant speed. If they die or get exiled, they go back to the Command zone. Beware! Each time you cast them, it costs an extra [2] mana. And if they get bounced into your hand or deck, they stay there.
5. Each player starts at 40 life.
6. if you take 21 damage total from any given Commander, you lose.
There are other rules, but that is what you need to know to get started. As far as how you should build them, that's still a hotly debated topic. Some say it should be a strictly Casual format and that we should refrain from anything too broken. An emphasis on design rather than function, flashy over forceful. Others say that the format opens up so much to us, that you shoudl build to win just as you would any other deck.
I myself keep two. I have a hyper-synergistic Sharuum the Hegemon deck that has multiple wincons and an aggressive tutor and ramp package to power them out. This is a tournament deck.
I also have a Skithiryx, the Blight Dragon deck I use as a Casual Griefer deck for late nights at the kitchen table. (It should be noted that both Mono-Black and Poison are bad EDH ideas unless you know the people you're playing with won't severely beat you.)