Protagonists:

Joe
(Akita Inu/Kishu Inu mix) Joe is one of Weed's brothers. He and Yukimura were fostered by a kind dog named Saheiji. A few months later from living in peace, a clan of monkeys led by an albinogelada baboon named Shougun battle Saheiji for his territory in the Southern Alps. Joe is taken away and thought to be eaten and dead. However, Joe is alive, having been rescued by a human who kept him as a pet. Joe also has a son by the named of Koujiro.

Yukimura
(Akita Inu/Kishu Inu mix) Yukimura is one of the three children of Gin and Sakura.He is the brother of Weed and Joe.When Sakura fell ill with a mysterious diease,a dog named Saheiji came and took Yukimura and Joe to be fostered by him,leaving Sakura to only have Weed.After awhile of peace,Joe and Yukimura one day run off into the woods.After the two wonder for a few hours,they turn to leave but then a clan of baboons,led by Shougun,attacks them.Yukimura fights fiercely to protect his brother,but Joe is captured when Yukimura is injured.Saheiji hears the pups' cries and rushs to the scene.But one of the monkeys snaps his spinal cord,and runs away with Joe.After Yukimura wakes from a deep coma,he finds his foster father lying beside him.He is told that Joe was taken and killed by the monkeys,a trail of blood is seen were the monkeys were carrying Joe.Yukimura swore to kill any monkeys that crosses paths with him.After a few months pass,Yukimura meets Weed.At first,Yukimura had no clue who Weed was,but when Weed says that Sakura had died from illness a few months ago,Yukimura remembers Weed,and his mother.Shougun again shows up and tries to kill Weed and Yukimura.But Yukimura defended Weed,just like he defended Joe.Sadly,after Shougun is killed by Yukimura,Yukimura dies a few seconds later from his injuries.

Lydia
(German Shepherd) The sister of Maxime and a pack member of Victor's. Her father was the leader of the large German Shepherd army until Victor took over. In the battle between Victor and Weed, she pretends to be injured so she can be taken away by Weed's army and gathering information. However, she quickly forgets all about it and falls in love with Jerome. Later, she and Maxime become followers of Ohu. She eventually gives birth to 6 puppies with her mate Jerome.

George
(Great Dane/Saluki mix) Ken's brother and Ben and Cross' son. He resembles his mother more than his father. He meets up with his brother and Weed while they look for the Koga dog Tesshin. He blames himself for his sister Miney's (also not shown in the anime) death when she jumped across a river to reach him and drowned.

Hakurō
(Siberian Husky) Hakuro returns in the manga after the battle with Akakabuto and raises his four sons in his large pack in Hokkaido. Months later, as the pups grow older, Victor and his group of Shepherds are trying to take Hakuro's territory. Victor and Hakuro fight, but as Hakuro twists in order to flee, his throat is torn open (Victor has his teeth around Hakuro's neck) and he tears loose his artery. Hakuro dies slowly after this.

Byakko, Genbu, and Seiryū
(Siberian Huskies) The brothers of Suzaku and sons of Hakuro. They help battle victor, but are killed in the process.

Suzaku
(Siberian husky) The brother of Seiryū, Byakko, and Genbu. Son of Hakuro. Suzaku does not participate in the war against Victor yet because he is nurturing his sons. Hakuro tells him to protect his grandsons, and Suzaku leaves them to his mate Hiromi. Suzaku finds out his father and brothers were killed, and he tries to get revenge by attacking Maxime, who has actually joined Ohu. Suzaku forgives Maxime for being a previous minion of Victor's and joins the war in order to keep his sons safe.

Kisaragi
(Siberian Husky) The former leader of the Four Mutsu Generals. After hearing about Hougen and Genba from Chutora's son Shigure, he sends his six sons to Ohu to aid Weed and the others in battle. Kisaragi stays behind because he fears he would not be of any help because of his old age.

Koyuki
(Kishu Inu) A female pet dog. When her younger brother, Kotetsu, goes missing, she goes out looks for him on her own. While walking along, she gets caught in a hunter's trap. Weed hears her cries and rescues her. Koyuki then develops a crush on Weed. When gets home, she tells her half-sister Chako what happened. Chako tells Koyuki that she was also rescued by a Shiba Inu named Sasuke. Suddenly, Koyuki's owner decides to send her away to become a breeding dog. Weed hears the news from her brother Kotetsu, he runs after the truck that's carrying her. He frees her and then Weed realizes his feelings toward Koyuki. However, Weed must return to defeat Victor, and he promises Koyuki he will see her again. The sequel to Ginga Densetsu Weed, Ginga Densetsu Weed: Orion, features her and Weed's four puppies.

Takeshi
(Doberman Pinscher) A young puppy in Kyoushiro's pack. He slipped into a river and was rescued by Toube, who was forced to bring the pup to Kamakiri as a hostage in order to spare his life. Takeshi later escapes Hougen with Kyoushiro as Toube fights off Kamakiri's pack.

Jaguar
(English Mastiff) Moss' son. He accompanies his father and the fighting dog Musashi to Ohu after hearing about Hougen's invasion on Futago Pass.

Chako
(Kishu Inu) Chako is the half-sister of Koyuki and Kotetsu. She was saved by the Shiba Inu, Sasuke, and has a crush on him, but later discovers that he was not the strong warrior he was lying to her about.

Wilson
(Rough Collie) A veteran from the battle against Akakabuto. He stays in Ohu and meets Weed during the Kaibutsu arc. At first, he doesn't believe that Weed is the son of Gin.


Antagonists:

Gon
(Akita-mix) A very minor character, Gon is the one who found Gin, Akame, and John resting in a hut. They captured him and he pleaded that he had to return to a family. Gin lets him go, and immediately he screams for Hougen and his army. Gon later bumps into GB and Sasuke, who are pretending to work for Hougen.

Miki
(Siberian husky) Brother of Hidari. He and Hidari were followers of a young dog called Sunshiro. They decided to take over his pack and torture the Borzoi pups Rocket, Missile, and Jet. Sunshiro begged for them to hurt him instead of the Borzois, so Miki and Hidari killed Sunshiro.

Hidari
(Siberian husky) Brother of Miki. He and Miki were followers of a young dog called Sunshiro. They decided to take over his pack and torture the Borzoi pups Rocket, Missile, and Jet. Sunshiro begged for them to hurt him instead of the Borzois, so Miki and Hidari killed Sunshiro.

Lucy
(Mastiff)She was the mate of Terry, the Mastiff who died in GNG by Akakabuto's minions. She grew jealous of Sakura, and told her that Gin was about to die in one of his missions, and that she should go see her husband before his end. She told Sakura that she regrets that she could not be by her husband at his death, so Sakura left to nurture her children in the woods. Lucy is the reason the Beardog family became separated.

Sniper
(Doberman Pinscher) In GNG, Sniper tried continuously to kill Gin and Ben in order to rule Ohu. After the fall in a river/gorge, Sniper has become incredibly handicapped. He has metal legs and blue pants on which help him walk. He has many scars on his body and a metal plate over the right side of his face. He joins Hougen.


Humans:

Daisuke
Gin's former owner and best friend. Daisuke has grown from an "adventurous little kid" into a young man. He hears about a monster (Kaibutsu) in Futago Pass that's been attacking people and killing them. Daisuke drives up to the mountain to see if it is true. On the way, he finds Weed, riddled with bullet wounds, and is speechless: The young dog is a Tora-ge, just like Gin. Positive that the puppy is Gin's son, Daisuke goes after him but then runs into Kaibutsu. Weed saves him and Kaibutsu is driven off by hunters and their rifles. Daisuke then takes Weed home and treats his wounds. After Weed is fully recovored, Daisuke lets him return to Futago Pass.

Hidetoshi
The former owner of John from GNG. He travels and hunts with Daisuke in order to stop the supposed dogs terrorizing people around the forest (Kaibutsu's actual doing.). Hidetoshi and Daisuke discover Kaibutsu and go to tell the village, confronting the old policeman Akira Sudou, who tells them of how his partner, Tanuma, was killed by the two Great Danes, Hougen and Genba. Hidetoshi helps in blowing up Gajou to stop Hougen from his reign of terror.

Shouji Sudou "The Mamushi"
Shouji is a one-eyed retired policeman who has an intense hatred for Hougen. Long ago, he and his partner, Tanuma, were in the Southern Alps on a mission to capture a criminal. There they found an abandoned kennel. As they inspect it inside, they saw Hougen and Genba with an army of their kin, eating a human. Then the dogs attacked the policemen. Though Shouji only lost his left eye, Tanuma was mercilessly torn apart by Hougen. Fuelled with hatred, Shouji swore to hunt down and kill Hougen for the loss of Tanuma. In the end, he finally found Hougen, heavily wounded and tired from the battle with Weed. Without an ounce of mercy for the defeated dog, Shouji shoots Hougen straight through the head with his rifle and avenges his friend. He is nicknamed "Shouji the Mamushi" for his tenacious spirit of hunting down criminals.

Iguchi
The previous owner of Ben. Ben shows up at his doorstep with the dead body of John. Iguchi understands that John was Ben's friend and helps him bury the body somewhere in the forest.

Tanuma
The police officer partner of Akira Sudou. He and Akira were trying to find a criminal when they spotted an abandoned kennel. They were attacked by Hougen and Genba, and Tanuma was killed. He was later avenged by Akira when he shot Hougen in the head several times.